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USC-OGP 2-DE database

Two-dimensional polyacrylamide gel electrophoresis database


USC-OGP 2-DE database 
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Searching in 'USC-OGP 2-DE database' for entry matching: TPM1_HUMAN




USC-OGP 2-DE database:  TPM1_HUMAN


TPM1_HUMAN


General information about the entry
View entry in simple text format
Entry nameTPM1_HUMAN
Primary accession numberP09493
integrated into USC-OGP 2-DE database on January 17, 2017 (release 1)
2D Annotations were last modified onJanuary 17, 2017 (version 1)
General Annotations were last modified on April 5, 2017 (version 2)
Name and origin of the protein
DescriptionRecName: Full=Tropomyosin alpha-1 chain; AltName: Full=Alpha-tropomyosin; AltName: Full=Tropomyosin-1;.
Gene nameName=TPM1
Synonyms=C15orf13, TMSA
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   2D GEL CHARACTERIZATION
Author 1., Author 2.
Submitted (Mar-2011) to Current
2D PAGE maps for identified proteins
How to interpret a protein

UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10}
Homo sapiens (Human)
UVEAL_MELANOMA_3-10
  map experimental info
 
UVEAL_MELANOMA_3-10

MAP LOCATIONS:
pI=4.66; Mw=34859
pI=5.28; Mw=34566
pI=4.73; Mw=33231

Cross-references
UniProtKB/Swiss-ProtP09493; TPM1_HUMAN.



2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 0.0
Entry nameTPM1_HUMAN
Primary accession numberP09493
Secondary accession number(s) B7Z5T7 D9YZV2 D9YZV3 D9YZV8 P09494 P10469 Q6DV89 Q6DV90 Q7Z6L8 Q86W64 Q96IK2 Q9UCI1 Q9UCI2 Q9UCY9 Q9Y427
Sequence was last modified on November 1, 1990 (version 2)
Annotations were last modified on March 15, 2017 (version 187)
Name and origin of the protein
DescriptionRecName: Full=Tropomyosin alpha-1 chain; AltName: Full=Alpha-tropomyosin; AltName: Full=Tropomyosin-1;
Gene nameName=TPM1
Synonyms=C15orf13, TMSA
Encoded onName=TPM1; Synonyms=C15orf13, TMSA
KeywordsAcetylation; Actin-binding; Alternative splicing; Cardiomyopathy; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Disease mutation; Muscle protein; Phosphoprotein; Reference proteome.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLM19267; AAA36771.1; -; mRNA
EMBLM19713; AAA61225.1; -; mRNA
EMBLM19714; AAA61226.1; -; mRNA
EMBLM19715; AAA61227.1; -; mRNA
EMBLAY640414; AAT68294.1; -; mRNA
EMBLAY640415; AAT68295.1; -; mRNA
EMBLAK299387; BAH13023.1; -; mRNA
EMBLAL050179; CAB43309.2; -; mRNA
EMBLGU324929; ADL14500.1; -; Genomic_DNA
EMBLGU324930; ADL14501.1; -; Genomic_DNA
EMBLGU324933; ADL14504.1; -; Genomic_DNA
EMBLGU324935; ADL14506.1; -; Genomic_DNA
EMBLAC079328; -; NOT_ANNOTATED_CDS; Genomic_DNA
EMBLCH471082; EAW77619.1; -; Genomic_DNA
EMBLCH471082; EAW77622.1; -; Genomic_DNA
EMBLCH471082; EAW77623.1; -; Genomic_DNA
EMBLCH471082; EAW77627.1; -; Genomic_DNA
EMBLCH471082; EAW77628.1; -; Genomic_DNA
EMBLBC007433; AAH07433.1; -; mRNA
EMBLBC050473; AAH50473.1; -; mRNA
EMBLBC053545; AAH53545.1; -; mRNA
EMBLX12369; CAA30930.1; -; mRNA
CCDSCCDS10181.1; -. [P09493-10]; .
CCDSCCDS32262.1; -. [P09493-7]; .
CCDSCCDS32263.1; -. [P09493-3]; .
CCDSCCDS32264.1; -. [P09493-5]; .
CCDSCCDS45273.1; -. [P09493-1]; .
CCDSCCDS58368.1; -. [P09493-8]; .
CCDSCCDS58369.1; -. [P09493-9]; .
PIRA27674; A27674; .
PIRA27678; A25825; .
PIRS05585; S05585; .
RefSeqNP_000357.3; NM_000366.5. [P09493-10]; .
RefSeqNP_001018004.1; NM_001018004.1. [P09493-9]; .
RefSeqNP_001018005.1; NM_001018005.1. [P09493-1]; .
RefSeqNP_001018006.1; NM_001018006.1. [P09493-3]; .
RefSeqNP_001018007.1; NM_001018007.1. [P09493-7]; .
RefSeqNP_001018008.1; NM_001018008.1. [P09493-5]; .
RefSeqNP_001018020.1; NM_001018020.1. [P09493-8]; .
RefSeqNP_001288173.1; NM_001301244.1. [P09493-6]; .
RefSeqNP_001317273.1; NM_001330344.1; .
RefSeqNP_001317275.1; NM_001330346.1; .
RefSeqNP_001317280.1; NM_001330351.1; .
UniGeneHs.133892; -; .
UniGeneHs.602995; -; .
ProteinModelPortalP09493; -; .
SMRP09493; -; .
BioGrid113021; 126; .
IntActP09493; 37; .
MINTMINT-1458755; -; .
iPTMnetP09493; -; .
PhosphoSitePlusP09493; -; .
SwissPalmP09493; -; .
BioMutaTPM1; -; .
DMDM136092; -; .
UCD-2DPAGEP09493; -; .
EPDP09493; -; .
MaxQBP09493; -; .
PeptideAtlasP09493; -; .
PRIDEP09493; -; .
DNASU7168; -; .
EnsemblENST00000267996; ENSP00000267996; ENSG00000140416. [P09493-7]; .
EnsemblENST00000288398; ENSP00000288398; ENSG00000140416. [P09493-10]; .
EnsemblENST00000334895; ENSP00000334624; ENSG00000140416. [P09493-5]; .
EnsemblENST00000358278; ENSP00000351022; ENSG00000140416. [P09493-3]; .
EnsemblENST00000403994; ENSP00000385107; ENSG00000140416. [P09493-1]; .
EnsemblENST00000559397; ENSP00000452879; ENSG00000140416. [P09493-8]; .
EnsemblENST00000559556; ENSP00000453941; ENSG00000140416. [P09493-9]; .
GeneID7168; -; .
KEGGhsa:7168; -; .
UCSCuc002alg.4; human. [P09493-1]; .
CTD7168; -; .
DisGeNET7168; -; .
GeneCardsTPM1; -; .
GeneReviewsTPM1; -; .
HGNCHGNC:12010; TPM1; .
HPACAB017698; -; .
HPAHPA000261; -; .
HPAHPA047089; -; .
HPAHPA053624; -; .
MalaCardsTPM1; -; .
MIM115196; phenotype; .
MIM191010; gene; .
MIM611878; phenotype; .
neXtProtNX_P09493; -; .
OpenTargetsENSG00000140416; -; .
Orphanet154; Familial isolated dilated cardiomyopathy; .
Orphanet155; Familial isolated hypertrophic cardiomyopathy; .
Orphanet54260; Left ventricular noncompaction; .
PharmGKBPA36690; -; .
GeneTreeENSGT00550000074494; -; .
HOGENOMHOG000231521; -; .
HOVERGENHBG107404; -; .
InParanoidP09493; -; .
KOK10373; -; .
PhylomeDBP09493; -; .
TreeFamTF351519; -; .
ReactomeR-HSA-390522; Striated Muscle Contraction; .
ReactomeR-HSA-445355; Smooth Muscle Contraction; .
ChiTaRSTPM1; human; .
GeneWikiTPM1; -; .
GenomeRNAi7168; -; .
PROPR:P09493; -; .
ProteomesUP000005640; Chromosome 15; .
BgeeENSG00000140416; -; .
ExpressionAtlasP09493; baseline and differential; .
GenevisibleP09493; HS; .
GOGO:0015629; C:actin cytoskeleton; IDA:HPA; .
GOGO:0005884; C:actin filament; IBA:GO_Central; .
GOGO:0032059; C:bleb; IMP:BHF-UCL; .
GOGO:0005856; C:cytoskeleton; TAS:UniProtKB; .
GOGO:0005829; C:cytosol; IDA:HPA; .
GOGO:0031941; C:filamentous actin; IEA:Ensembl; .
GOGO:0005862; C:muscle thin filament tropomyosin; TAS:ProtInc; .
GOGO:0032587; C:ruffle membrane; IDA:BHF-UCL; .
GOGO:0030017; C:sarcomere; TAS:BHF-UCL; .
GOGO:0001725; C:stress fiber; IDA:BHF-UCL; .
GOGO:0003779; F:actin binding; TAS:BHF-UCL; .
GOGO:0051015; F:actin filament binding; IBA:GO_Central; .
GOGO:0008092; F:cytoskeletal protein binding; IPI:UniProtKB; .
GOGO:0005200; F:structural constituent of cytoskeleton; TAS:BHF-UCL; .
GOGO:0008307; F:structural constituent of muscle; TAS:ProtInc; .
GOGO:0007015; P:actin filament organization; IBA:GO_Central; .
GOGO:0060048; P:cardiac muscle contraction; IMP:BHF-UCL; .
GOGO:0034614; P:cellular response to reactive oxygen species; IEP:BHF-UCL; .
GOGO:0007010; P:cytoskeleton organization; TAS:BHF-UCL; .
GOGO:0001701; P:in utero embryonic development; IEA:Ensembl; .
GOGO:0006928; P:movement of cell or subcellular component; TAS:UniProtKB; .
GOGO:0006936; P:muscle contraction; TAS:Reactome; .
GOGO:0030049; P:muscle filament sliding; ISS:BHF-UCL; .
GOGO:0030336; P:negative regulation of cell migration; ISS:BHF-UCL; .
GOGO:1904753; P:negative regulation of vascular associated smooth muscle cell migration; IMP:BHF-UCL; .
GOGO:1904706; P:negative regulation of vascular smooth muscle cell proliferation; IMP:BHF-UCL; .
GOGO:0032781; P:positive regulation of ATPase activity; ISS:BHF-UCL; .
GOGO:0045785; P:positive regulation of cell adhesion; ISS:BHF-UCL; .
GOGO:0003065; P:positive regulation of heart rate by epinephrine; ISS:BHF-UCL; .
GOGO:0051496; P:positive regulation of stress fiber assembly; ISS:BHF-UCL; .
GOGO:0008360; P:regulation of cell shape; IMP:BHF-UCL; .
GOGO:0008016; P:regulation of heart contraction; TAS:ProtInc; .
GOGO:0006937; P:regulation of muscle contraction; TAS:ProtInc; .
GOGO:0031529; P:ruffle organization; ISS:BHF-UCL; .
GOGO:0045214; P:sarcomere organization; IMP:BHF-UCL; .
GOGO:0055010; P:ventricular cardiac muscle tissue morphogenesis; IMP:BHF-UCL; .
GOGO:0042060; P:wound healing; ISS:BHF-UCL; .
InterProIPR000533; Tropomyosin; .
PfamPF00261; Tropomyosin; 1; .
PRINTSPR00194; TROPOMYOSIN; .
PROSITEPS00326; TROPOMYOSIN; 1; .



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Database constructed and maintained by Angel Garcia, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server

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